The story starts with an incident taking place in 12th century during the rule of the Chozha dynasty when Hindus were divided into Saivites and Vaishnavites. Rangarajan Nambi (Avatar No.1) is a loyal disciple of Ramanuja Azhwar. King Kulothunga (Napolean - what a fantastic performance!), a follower of Lord Siva, compels Nambi to change his religious beliefs and worship Lord Siva instead of Lord Vishnu but Nambi refuses.
After this meaningless first avatar, the movie shifts to the present scientific world. Govind (Avatar No.2), an American scientist invents a dangerous bio weapon in his lab but wants to destroy the same after realizing its dangerous consequences. But the US Govt and scientists don't allow him to do that. One fine day, Govind runs away from the lab with the bio weapon but Fletcher (Avatar No.3), a former CIA officer turned villian, chases him to get the weapon back to destroy other countries.
The weapon is mistakenly sent to an Indian address by courier where a 95 year old lady (Avatar No.4) receives the parcel. Govind immediately rushes to India and traces down the address. He is followed by Fletcher who is accompanied by his prostitute cum translator (Mallika Sherawat). The old lady refuses to give the weapon to them without understanding the danger it could cause and puts it inside a statue of Lord Vishnu. More>>